Cannabidiol for Oral Health: A New Promising Therapeutical Tool in Dentistry

Luigi Bellocchio (1) , Assunta Patano (2) , Alessio Danilo Inchingolo (2) , Francesco Inchingolo (2) , Gianna Dipalma (2) , Ciro Gargiulo Isacco (2) , Elisabetta de Ruvo (2) , Biagio Rapone (2) , Antonio Mancini (2) , Felice Lorusso (3) , Antonio Scarano (3) , Giuseppina Malcangi (2) , Angelo Michele Inchingolo (2)

1 U1215 Inserm - UB - Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale
2 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
3 University of Chieti-Pescara

The medical use of cannabis has a very long history. Although many substances called cannabinoids are present in cannabis, Δ9tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD) and cannabinol (CBN) are the three main cannabinoids that are most present and described. CBD itself is not responsible for the psychotropic effects of cannabis, since it does not produce the typical behavioral effects associated with the consumption of this drug. CBD has recently gained growing attention in modern society and seems to be increasingly explored in dentistry. Several subjective findings suggest some therapeutic effects of CBD that are strongly supported by research evidence. However, there is a plethora of data regarding CBD’s mechanism of action and therapeutic potential, which are in many cases contradictory. We will first provide an overview of the scientific evidence on the molecular mechanism of CBD’s action. Furthermore, we will map the recent developments regarding the possible oral benefits of CBD. In summary, we will highlight CBD’s promising biological features for its application in dentistry, despite exiting patents that suggest the current compositions for oral care as the main interest of the industry. © 2023 by the authors.

Mots clés: Plants; Cannabinoids; CBD; Pharmacology; Dental medicine; Patents

Domaines: Neurosciences [q-bio.NC]

Luigi Bellocchio, Assunta Patano, Alessio Danilo Inchingolo, Francesco Inchingolo, Gianna Dipalma, et al.. Cannabidiol for Oral Health: A New Promising Therapeutical Tool in Dentistry. International Journal of Molecular Sciences, 2023, 24 (11), ⟨10.3390/ijms24119693⟩. ⟨hal-04475156⟩