Towards an understanding of the epigenetics of schistosomes: a comparative epigenomic study

Abstract : As in perhaps all eurkaryotes, schistosomes use a supplementary information transmitting system, the epigenetic inheritance system, to shape genetic information and to produce different phenotypes. In contrast to other important parasites, the study of epigenetic phenomena in schistosomes is still in its infancy. Nevertheless, we are beginning to grasp what goes on behind the epigenetic scene in this parasite. We have developed techniques of native chromatin immunoprecipitation (N-ChIP) and associated the necessary bioinformatics tools that allow us to run genome-wide comparative chromatin studies on Schistosoma mansoni at different stages of its life cycle, on different strains and on different sexes. We present here an application of such an approach to study the genetic and epigenetic basis for a phenotypic trait, the compatibility of S. mansoni with its invertebrate host Biomphalaria glabrata. We have applied the ChIP procedure to two strains that are either compatible or incompatible with their intermediate host. The precipitated DNA was sequenced and aligned to a reference genome and this information was used to determine regions in which both strands differ in their genomic sequence and/or chromatin structure. This procedure allowed us to identify candidate genes that display either genetic or epigenetic difference between the two strains.
Document type :
Journal articles
Complete list of metadatas

Cited literature [31 references]  Display  Hide  Download
Contributor : Anne Modat <>
Submitted on : Monday, April 1, 2019 - 3:45:39 PM
Last modification on : Wednesday, April 10, 2019 - 9:39:05 AM
Long-term archiving on : Tuesday, July 2, 2019 - 6:11:46 PM


Publisher files allowed on an open archive


  • HAL Id : halsde-00643863, version 1


J. M. J. Lepesant, C. Grunau, C. Cosseau. Towards an understanding of the epigenetics of schistosomes: a comparative epigenomic study. Memorias do Instituto Oswaldo Cruz, 2011, 106 (7), pp.823-830. ⟨halsde-00643863⟩



Record views


Files downloads