Associations between persistent organic pollutants and risk of breast cancer metastasis

Meriem Koual (1, 2, 3) , Germán Cano-Sancho , Anne-Sophie Bats (1, 2, 3) , Céline Tomkiewicz (1, 3) , Yael Kaddouch-Amar (1, 3) , Nathalie Douay-Hauser , Charlotte Ngo , Hélène Bonsang (1, 2) , Myriam Deloménie (1, 2) , Fabrice Lecuru (1, 3, 2) , Bruno Le Bizec , Philippe Marchand , Jérémie Botton , Robert Barouki (1, 2, 3) , Jean-Philippe Antignac , Xavier Coumoul

1 UPCité - Université Paris Cité
2 HEGP - Hôpital Européen Georges Pompidou [APHP]
3 T3S - UMR_S 1124 - Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire

Background: Breast cancer (BC) is a major public health concern with over 2 million new cases diagnosed and over 600,000 deaths in 2018 in women worldwide. When distant metastases are present at diagnosis, the 5-year survival rate is only 26%. Recent studies have suggested that persistent organic pollutants (POPs) that accumulate in adipose tissue (AT) can influence tumor phenotype and stimulate cellular processes important for metastasis such as invasion. We, therefore, tested the hypothesis that POP exposure is associated with BC me-tastasis. Methods: We conducted an exploratory case-control study in which the concentrations of 49 POPs were measured in both AT and serum samples from BC patients, with or without lymph node metastasis, who underwent partial or total mastectomies, lymph node biopsies and sampling of the adipocytic tumor microenvironment. Adjusted, unconditional logistic models were used to study the associations between the POP concentrations and the risk of metastasis and other hallmarks of cancer aggressiveness. Results: 2.3.7.8-TCDD concentrations in AT are positively associated with the risk of metastasis in 43 patients who have BMIs equal or higher than 25 kg/m2 (odds ratio: 4.48 (1.32-20.71)). Furthermore, the concentrations of 2.3.7.8-TCDD and two coplanar PCBs (77&169) in AT also were positively associated with the risk of lymph node metastasis and the tumor size. Conclusion: Our study suggests that 2.3.7.8-TCDD and some PCBs contribute to the development of tumor metastasis and other hallmarks of cancer aggressiveness. While these results should be considered with caution, this is the first study to identify such potential risk factors. Larger longitudinal studies are necessary to confirm our results. Clinical Trial Protocol Record: 2013-A00663-42.

Mots clés: Adipose tissue; Breast cancer; Endocrine disrupting chemicals; Perfluoroalkyl acid; Polychlorinated biphenyls; Serum

Mots clés: Dioxins; Environmental exposure; Organochlorine pesticides

Domaines: Toxicologie et chaîne alimentaire; Chimie analytique; Environnement et Société; Cancer; Santé; Santé publique et épidémiologie; Sciences de l'Homme et Société

Meriem Koual, Germán Cano-Sancho, Anne-Sophie Bats, Céline Tomkiewicz, Yael Kaddouch-Amar, et al.. Associations between persistent organic pollutants and risk of breast cancer metastasis. Environment International, 2019, 132, pp.105028. ⟨10.1016/j.envint.2019.105028⟩. ⟨hal-02263282⟩