Genome Content and Phylogenomics Reveal both Ancestral and Lateral Evolutionary Pathways in Plant-Pathogenic Streptomyces Species

Abstract : Streptomyces spp. are highly differentiated actinomycetes with large, linear chromosomes that encode an arsenal of biologically active molecules and catabolic enzymes. Members of this genus are well equipped for life in nutrient-limited environments and are common soil saprophytes. Out of the hundreds of species in the genus Streptomyces, a small group has evolved the ability to infect plants. The recent availability of Streptomyces genome sequences, including four genomes of pathogenic species, provided an opportunity to characterize the gene content specific to these pathogens and to study phylogenetic relationships among them. Genome sequencing, comparative genomics, and phylogenetic analysis enabled us to discriminate pathogenic from saprophytic Streptomyces strains; moreover, we calculated that the pathogen-specific genome contains 4,662 orthologs. Phylogenetic recon- struction suggested that Streptomyces scabies and S. ipomoeae share an ancestor but that their biosynthetic clusters encoding the required virulence factor thaxtomin have diverged. In contrast, S. turgidiscabies and S. acidiscabies, two relatively unrelated pathogens, possess highly similar thaxtomin biosynthesis clusters, which suggests that the acquisition of these genes was through lateral gene transfer.
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Applied and Environmental Microbiology, American Society for Microbiology, 2016, 82 (7), pp.2146-2153. 〈10.1128/AEM.03504-15.〉
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Soumis le : jeudi 9 juin 2016 - 11:31:04
Dernière modification le : jeudi 19 avril 2018 - 14:28:02

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José Huguet-Tapia, Tristan Lefébure, Jonathan H Badger, Dongli Guan, Gregg S. Pettis, et al.. Genome Content and Phylogenomics Reveal both Ancestral and Lateral Evolutionary Pathways in Plant-Pathogenic Streptomyces Species. Applied and Environmental Microbiology, American Society for Microbiology, 2016, 82 (7), pp.2146-2153. 〈10.1128/AEM.03504-15.〉. 〈hal-01329447〉

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