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Article Dans Une Revue Nature Communications Année : 2020

A high-stringency blueprint of the human proteome

1 Macquarie University
2 Monash University [Melbourne]
3 ISB - Institute for Systems Biology [Seattle]
4 CMU - Centre médical universitaire de Genève
5 University of Michigan [Ann Arbor]
6 UCD - University College Dublin [Dublin]
7 Yonsei University
8 UBC - University of British Columbia
9 CNB-CSIC - Centro Nacional de Biotecnología [Madrid]
10 Princeton University
11 Cedars-Sinai Medical Center
12 KTH - KTH Royal Institute of Technology [Stockholm]
13 Uppsala University
14 Johns Hopkins University School of Medicine [Baltimore]
15 ASU - Arizona State University [Tempe]
16 NIH - National Institutes of Health [Bethesda, MD, USA]
17 NCI-NIH - National Cancer Institute [Bethesda]
18 Bruker Daltonik GmbH
19 David Geffen School of Medicine [Los Angeles]
20 University of Nebraska Medical Center
21 IIT Bombay - Indian Institute of Technology Bombay
22 PUC-Rio - Pontifícia Universidade Católica do Rio de Janeiro [Brasil] = Pontifical Catholic University of Rio de Janeiro [Brazil] = Université catholique pontificale de Rio de Janeiro [Brésil]
23 BGE - UMR S1038 - Laboratoire de Biologie à Grande Échelle
24 University of Colorado Anschutz [Aurora]
25 EMBL-EBI - European Bioinformatics Institute [Hinxton]
26 UNSW - University of New South Wales [Sydney]
27 UC San Diego - University of California [San Diego]
28 CSE - UC San Diego - Department of Computer Science and Engineering [Univ California San Diego]
29 Skane University Hospital [Lund]
30 University of Texas Health Science Center
31 Irset - Institut de recherche en santé, environnement et travail
32 LUMC - Leiden University Medical Center
33 Stanford University School of Medicine [CA, USA]
34 UZH - Universität Zürich [Zürich] = University of Zurich
35 Stanford School of Medicine [Stanford]
S Adhikari
  • Fonction : Auteur
Lydie Lane
  • Fonction : Auteur
  • PersonId : 953536
Young-Ki Paik
  • Fonction : Auteur
Fuchu He
  • Fonction : Auteur
Peter Stewart
  • Fonction : Auteur
Gilberto B Domont
  • Fonction : Auteur

Résumé

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
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Dates et versions

hal-03004830 , version 1 (28-05-2021)

Identifiants

Citer

S Adhikari, Edouard C Nice, E Deutsch, Lydie Lane, Gilbert S Omenn, et al.. A high-stringency blueprint of the human proteome. Nature Communications, 2020, 11 (1), pp.5301. ⟨10.1038/s41467-020-19045-9⟩. ⟨hal-03004830⟩
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