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Article Dans Une Revue Mathematical Modelling of Natural Phenomena Année : 2011

Application of Hybrid Models to Blood Cell Production in the Bone Marrow

Résumé

A hybrid model of red blood cell production, where cells are considered as discrete objects while intra-cellular proteins and extra-cellular biochemical substances are described with continuous models, is proposed. Spatial organization and regulation of red blood cell production (erythropoiesis) are investigated. Normal erythropoiesis is simulated in two dimensions, and the influence on the output of the model of some parameters involved in cell fate (differentiation, self-renewal, and death by apoptosis) is studied.
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Dates et versions

hal-00649217 , version 1 (29-05-2020)

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Nikolai Bessonov, Fabien Crauste, Stephan Fisher, Polina Kurbatova, Vitaly Volpert. Application of Hybrid Models to Blood Cell Production in the Bone Marrow. Mathematical Modelling of Natural Phenomena, 2011, 6 (7), pp.2-12. ⟨10.1051/mmnp/20116701⟩. ⟨hal-00649217⟩
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