Evidence for Specific Genotype-Dependent Immune Priming in the Lophotrochozoan Biomphalaria glabrata Snail.

Julien Portela (1) , David Duval (1) , Anne Rognon (1) , Richard Galinier (1) , Jérôme Boissier (1) , Christine Coustau (2) , Guillaume Mitta (1) , André Théron (1) , Benjamin Gourbal (1)

1 2EI - Ecologie et évolution des interactions [2011-2014]
2 IBSV - Interactions Biotiques et Santé Végétale

Historically, the prevailing view in the field of invertebrate immunity was that invertebrates that do not possess acquired adaptive immunity rely on innate mechanisms with low specificity and no memory. Several recent studies have shaken this paradigm and suggested that the immune defenses of invertebrates are more complex and specific than previously thought. Mounting evidence has shown that at least some invertebrates (mainly Ecdysozoa) show high levels of specificity in their immune responses to different pathogens, and that subsequent reexposure may result in enhanced protection (recently called 'immune priming'). Here, we investigated immune priming in the Lophotrochozoan snail species Biomphalaria glabrata, following infection by the trematode pathogen Schistosoma mansoni. We confirmed that snails were protected against a secondary homologous infection whatever the host strain. We then investigated how immune priming occurs and the level of specificity of B. glabrata immune priming. In this report we confirmed that immune priming exists and we identified a genotype-dependent immune priming in the fresh-water snail B. glabrata.

Mots clés: Genotype; Biomphalaria glabrata; Immune priming; Specificity; Lophotrochozoan

Domaines: Biodiversité et Ecologie

Julien Portela, David Duval, Anne Rognon, Richard Galinier, Jérôme Boissier, et al.. Evidence for Specific Genotype-Dependent Immune Priming in the Lophotrochozoan Biomphalaria glabrata Snail.. Journal of Innate Immunity, 2013, 5 (3), pp.261-276. ⟨10.1159/000345909⟩. ⟨halsde-00790554⟩