Vertebrate host protective immunity drives genetic diversity and antigenic polymorphism in Schistosoma mansoni. - HAL-SDE - Sciences de l'environnement Accéder directement au contenu
Article Dans Une Revue Journal of Evolutionary Biology Année : 2011

Vertebrate host protective immunity drives genetic diversity and antigenic polymorphism in Schistosoma mansoni.

Résumé

Schistosomes are gonochoric blood parasites with a complex life cycle responsible for a disease of considerable medical and veterinary importance in tropical and subtropical regions. Understanding the evolution of schistosome genetic diversity is clearly of fundamental importance to interpreting schistosomiasis epidemiology and disease transmission patterns of this parasite. In this article, we investigated the putative role of the host immune system in the selection of male genetic diversity. We demonstrated the link between genetic dissimilarity and the protective effect among male worms. We then compared the proteomes of three male clones with different genotypes and differing by their capacity to protect against reinfection. The identified differences correspond mainly to antigens known or supposed to be involved in the induction of protective immunity. These results underline the role played by host immune system in the selection of schistosome genetic diversity that is linked to antigenic diversity. We discuss the evolutionary consequences in the context of schistosome infection.
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Dates et versions

halsde-00580773 , version 1 (29-03-2011)

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S. Beltran, Benjamin Gourbal, Jérôme Boissier, David Duval, S. Kieffer-Jaquinod, et al.. Vertebrate host protective immunity drives genetic diversity and antigenic polymorphism in Schistosoma mansoni.. Journal of Evolutionary Biology, 2011, 24 (3), pp.554-72. ⟨10.1111/j.1420-9101.2010.02190.x⟩. ⟨halsde-00580773⟩
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