In vitro activities of trioxaquines against Schistosoma mansoni.

Jérôme Boissier (1) , Frédéric Coslédan (2) , Anne Robert (3) , B. Meunier (2)

1 BETM - Biologie et écologie tropicale et méditerranéenne [2007-2010]
2 Palumed - Palumed
3 LCC - Laboratoire de chimie de coordination

We report the in vitro activities of trioxaquines against larval and adult-stage schistosomes at 5 and 50 microg/ml, respectively. Such activities are equivalent to that of praziquantel, the major and rather unique drug currently used for the treatment of schistosomiasis. In this range of concentrations, artemisinin derivatives (artesunate and artemether) have no activity.

Domaines: Biodiversité et Ecologie

Jérôme Boissier, Frédéric Coslédan, Anne Robert, B. Meunier. In vitro activities of trioxaquines against Schistosoma mansoni.. Antimicrobial Agents and Chemotherapy, 2009, 53 (11), pp.4903-6. ⟨10.1128/AAC.00640-09⟩. ⟨halsde-00431813⟩