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| HAL: halsde-00305195, version 1 |
| DOI: 10.1016/j.phytochem.2008.03.010 |
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| Phytochemistry 69 (2008) 1933-1938 |
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| Sesquiterpenes from aerial parts of Ferula vesceritensis |
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| Karima Oughlissi-Dehak 1, 2Philippe Lawton 3 |
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| (2008) |
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| From the dichloromethane extract of aerial parts of Ferula vesceritensis (Apiaceae), 11 sesquiterpene derivatives were isolated. Among them five were compounds designated as 10-hydroxylancerodiol-6- anisate, 2,10-diacetyl-8-hydroxyferutriol-6-anisate, 10-hydroxylancerodiol-6-benzoate, vesceritenone and epoxy-vesceritenol. The six known compounds were identified as feselol, farnesiferol A, lapidol, 2-acetyl-jaeschkeanadiol-6-anisate, lasidiol-10-anisate and 10-oxo-jaesckeanadiol-6-anisate. All the structures were determined by extensive spectroscopic studies including 1D and 2D NMR experiments and mass spectroscopy analysis. Two of the compounds, the sesquiterpene coumarins farnesiferol A and feselol, bound to the model recombinant nucleotide-binding site of an MDR-like efflux pump from the enteropathogenic protozoan Cryptosporidium parvum. |
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| 1: | Ecologie microbienne (EM) |
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CNRS : UMR5557 – INRA : UR1193 – Université Claude Bernard - Lyon I – Ecole Nationale Vétérinaire de Lyon |
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| 2: | Laboratoire de Biogéochimie en Milieux Désertiques |
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Université Kasdi Merbah |
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| 3: | Laboratoire de Parasitologie |
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Université de Lyon |
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| 4: | Laboratoire d'Analyse Organique Fonctionnelle |
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Université des Sciences et de la Technologie Houari Boumediène |
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| subject | : | Environmental Sciences/Biodiversité et Ecologie Life Sciences/Pharmaceutical sciences Life Sciences/Pharmaceutical sciences/Medication Life Sciences/Vegetal Biology |
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| Ferula vesceritensis Apiaceae Sesquiterpene P-Glycoprotein MDR Cryptosporidium parvum |
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| halsde-00305195, version 1 | |
| http://hal-sde.archives-ouvertes.fr/halsde-00305195 | |
| oai:hal-sde.archives-ouvertes.fr:halsde-00305195 | |
| From: Christine Delorme | |
| Submitted on: Wednesday, 23 July 2008 14:32:53 | |
| Updated on: Wednesday, 23 July 2008 14:32:53 | |
